Table of Contents 1. Co-Immunoprecipitation Methods for Detection of G Protein-Coupled Receptors in Brain Tissue Kazunori Namba and Hiroki Kaneko 2. Co-Immunoprecipitation Methods to Identify Associated Proteins with Estrogen Receptor at Postsynaptic Density in Brain Tissue Gen Murakami and Suguru Kawato 3. Use of Co-Immunoprecipitation to Study Conformation-Specific protein Interactions of Oligomeric -Synuclein Aggregates Cristine Betzer, Rikke Hahn Kofoed, Poul Henning Jensen 4. Using Co-Immunoprecipitation and Shotgun Mass Spectrometry for protein-Protein Interaction Identification in Cultured Human Oligodencrocytes Bradley Smith, Daniel Martins-de-Souza, and Mariana Fioramonte 5. Co-Immunoprecipition Analysis of GPCR Complexes in the Central Nerve System Yuji Kamikubo and Takashi Sakurai 6. The Histoblot Technique: A Reliable Approach to Analyse Expression Profile of proteins and to Predict their Molecular Association Carolina Aguado and Rafael Luján 7. Co-Immunoprecipitation Assay to Investigate the Interaction Strength between Synaptic Protein using COS-7 Cells Sosuke Yagishita 8. Guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTP S) Binding/Immunoprecipitation Assay Using Magnetic Beads Coated with Anti-G Antibody in Mammalian Brain Membranes Yjui Odagaki 9. Co-Immunoprecipitation as a Useful Tool for Detection of G protein-Coupled Receptors Oligomers Kirill Shumilov, Alejandra Valderrama-Carvajal, Maria Garcia-Bonilla, and Alicia Rivera 10. Isolation and Detection of G Protein-Coupled receptor (GPCR) Heteroreceptor Complexes in Rat Brain Synaptosomal Preparation using a Combined Brain Subcellular Fractionation/Co-Immunoprecipitation (co-IP) Procedures Dasiel O. Borroto-Escuela, Manuel Narvaez, Martina Zannoni, Chiara Contri, Minerva Crespo-Ramírez, Michael di Palma, Patrizia Ambrogini, Daily Y. Borroto-Escuela, Ismel Brito, Mariana Pita-Rodríguez, Ismael Valladolid-Acebes, Miguel Pérez de la Mora and Kjell Fuxe 11. Co-Immunoprecipitation of Membrane-Bound Receptors from Subsynaptic Compartments Wilber Romeo-Fernandez, Maria Garcia-Barcelo, and Yunis Perez-Betancourt 12. Co-Immunoprecipitation (co-IP) Analysis for Protein-Protein Interactions in the Neurons of the Cerebral Ganglia of the Land Snails of the Genus Polymita during Aestivation Daily Y. Borroto-Escuela, Idania Herández-Ramos, Kjell Fuxe and Dasiel O. Borroto-Escuela 13. Co-Immunoprecipitation (co-IP) of G Protein-Coupled Receptors (GPCR)-Receptor Tyrosine Kinases (RTK) Complexes from the Dorsal Hippocampus of the Rat Brain Michael Di Palma, Manuel Narvaez, Mariana Pita-Rodríguez, Chiara Contri, Martina Zannoni, Riccardo Cuppini, Kjell Fuxe, Patrizia Ambrogini and Dasiel O. Borroto-Escuel