Necessary basics: elements, isotopes, ions, chemical reactions, energy metabolism and bacterial structures.- Photosynthesis and sucrose production.- The connective tissue extracellular matrix and its major components.- Fibrillar and non-fibrillar collagens & its integrin attachments.- Basal laminas and epithelia.- Elastic fibers and proteoglycans.- Collagen synthesis, genetic diseases and scurvy.- The zincins: collagen fiber processing and degradation.- Biological mineralization.- Bone remodeling and calcium metabolism.- Blood Coagulation.- Saliva.- Chronic Periodontitis.- Aggressive Periodontitis.- Dental caries.- Fluoride.