Foreword Introduction Chapter 1: From DNA Replication to Genome Instability in Schizosaccharomyces pombe: Pathways to Cancer by Julie M. Bailis and Susan L. Forsburg Chapter 2: Dissecting Layers of Mitotic Regulation Essential for Maintaining Genomic Stability by Jeffiner S. Searle and Yolanda Sanchez Chapter 3: Yeast as a Tool in Cancer Research: Nuclear Trafficking by Anita H. Corbett and Adam C. Berger Chapter 4: Studies of Protein Farnesylation in Yeast by Nitika Thaper and Fuyuhiko Tamanoi Chapter 5: From Bread to Bedside: What Budding Yeast has Taught us about the Immortalization of Cancer Cells by Soma S.R. Banik and Christopher M. Counter Chapter 6: Hsp90 Co-chaperones in Saccharomyces Cerevisiae by Marija Tesiccc and Richard F. Gaber Chapter 7: Yeast as a Model System for Studying Cell Cycle Checkpoints by Carmela Palermo and Nancy C. Walworth Chapter 8: Metabolism and Function of Sphingolipids in Saccharomyces Cerevisiae: Relevance to Cancer Research by L. Ashley Cowart, Yusuf A. Hannun, and Lina M. Obeid Chapter 9: Exploring and Restoring the p53 Pathway Using the p53 Dissociator Assay in Yeast by Rainer K. Brachmann Chapter 10: Functional Analysis of the Human p53 Tumor Suppressor and its Mutants using Yeast by Alberto Inga, Francesca Storici and Michael A. Resnick Chapter 11: ABC Transporters in Yeast - Drug Resistance and Stress Response in a Nutshell by Karl Kuchler and Christoph Schüller Chapter 12: The FHCRC/NCI Yeast Anticancer Drug Screen by Susan L. Holbeck and Julian Simon Chapter 13: Yeas as a Model to Study the Immunosuppressive and Chemotherapeutic Drug Rapamycin by John R. Rohde, Sara A. Zurita-Martinez, and Maria E. Cardenas Chapter 14: Use of Yeast as a Model of System for Identifying and Studying Anti-Cancer Drugs by Jun O. Liu and Julian A. Simon Chapter 15: Genetic Analysis of CisplatinResistance in Yeast and Mammals by Seiko Ishida and Ira Herskowitz Chapter 16: Using Yeast Tools to Dissect the Action of Anti-Cancer Drugs: Mechanisms of Enzyme Inhibition and Cell Killing by Agents Targeting DNA Topoisomerases by Anna Rogojina, David Li, Karin C. Nitiss, and John L. Nitiss