PART I: GENERAL ASPECTS New Trends in Drug Discovery Patenting Drugs and Biologics PART II: DRUG CLASSES Evolution of Non-steroidal Androgen Receptor Antagonists Kinase Inhibitor Drugs PART III: CASE HISTORIES T-Cell-engaging Bispecific Antibody Construct Blinatumomab for Treatment of Patients with Relapsed and Refractory Acute B-Lymphoblastic Leukemia Successful Drug Discovery : Ceritinib Discovery and Mechanisms of Action of the CD38-targeting Antibody Daratumomab The Discovery of Obeticholic Acid (OCALIVA), First in Class FXR Agonist Discovery and Development of Obinutuzumab, a Glycoengineered Type II CD20 Antibody Omarigliptin (Marizev): A Once-weekly Oral Antidiabetic Agent Opicapone, a Novel Catechol-O-Methyltransferase Inhibitor to Manage the Symptoms of Parkinson's Disease The Discovery of Osimertinib Discovery of Pitolisant; the first marketed histamine H3-receptor inverse agonist/ antagonist for treating narcolepsy Discovery and Development of Safinamide, a New Drug for the Treatment of Parkinson's Disease Discovery of Trifluridine/Tipiracil sakriti opis