Part I: Introduction

Hematopoiesis and Bone Marrow Histology

Bone Marrow Examination and Techniques

Bone Marrow Reporting

Overview of Constitutional and Acquired Bone Marrow Disorders

Part II: Anemia

Overview of Anemia

SECTION 1: ACQUIRED ANEMIAS

Iron Deficiency Anemia

Autoimmune Hemolytic Anemias

Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn

Microangiopathic Hemolytic Anemia

Megaloblastic Anemia

Acquired Nonneoplastic Sideroblastic Anemia

Alcoholism-Associated Anemia

Anemia in the Elderly

Copper Deficiency-Associated Anemia

Acquired Red Cell Aplasia

Transient Erythroblastopenia of Childhood

Parvovirus-Induced Red Cell Aplasia

Paroxysmal Nocturnal Hemoglobinuria

Acquired Aplastic Anemia

SECTION 2: CONSTITUTIONAL ANEMIAS

Thalassemia

Sickle Cell Anemia

Pyruvate Kinase Deficiency

Hereditary Spherocytosis

Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis

Diamond-Blackfan Anemia

Fanconi Anemia

Congenital Dyserythropoietic Anemia

Congenital Sideroblastic Anemia

Congenital Megaloblastic Anemia

Part III: Erythrocytosis

SECTION 1: CONSTITUTIONAL

Congenital Erythrocytosis

SECTION 2: ACQUIRED

Acquired Erythrocytosis

Part IV: Benign Leukocyte Disorders in Blood and Bone Marrow

Overview of Benign Leukocyte Disorders in Blood and Bone Marrow

Pancytopenia

Neutropenia

Neutrophilia

Monocytosis

Eosinophilia

Basophilia

Lymphocytosis

Lymphopenia, Constitutional and Acquired

Plasmacytosis of Bone Marrow

Hematogones in Bone Marrow

Lymphoid Aggregates in Bone Marrow

Granulomas in Bone Marrow

Part V: Constitutional Granulocytic Disorders

SECTION 1: CONSTITUTIONAL NEUTROPENIAS

Severe Congenital Neutropenia and Cyclic Neutropenia

Shwachman-Diamond Syndrome

Chediak-Higashi Syndrome

Myelokathexis in WHIM Syndrome

SECTION 2: CONSTITUTIONAL NEUTROPHIL ANOMALIES

Pelger-Huet Anomaly

MYH9-Related Disorders

Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation

Part VI: Megakaryocytic Disorders

Overview of Megakaryocytic Disorders

SECTION 1: ACQUIRED PLATELET DISORDERS WITH THROMBOCYTOPENIA

Immune-Mediated Thrombocytopenia

Hemolytic-Uremic Syndrome

Thrombotic Thrombocytopenic Purpura

Pregnancy-Associated Thrombocytopenia

SECTION 2: CONSTITUTIONAL PLATELET DISORDERS WITH THROMBOCYTOPENIA

Thrombocytopenia Absent Radius Syndrome

Congenital Amegakaryocytic Thrombocytopenia

Gray Platelet Syndrome

Wiskott-Aldrich Syndrome-Related Disorders

Congenital Thrombotic Thrombocytopenic Purpura

SECTION 3: THROMBOCYTOSIS

Thrombocytosis

Part VII: Infection

Overview of Infection

Hantavirus Pulmonary Syndrome

Human Immunodeficiency Virus

Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus)

Parvovirus B19 Infection

Bacterial Infections, Blood and Bone Marrow Features

Fungal Infections, Blood and Bone Marrow Features

Helminthic Infections

Malaria

Other Protozoan Infections

Part VIII: Miscellaneous Nonneoplastic Disorders and Conditions

Overview and Classification of Hemophagocytic Disorders in Bone Marrow

Hematologic Manifestations of Collagen Vascular Disorders

Hematologic Manifestations of Chronic Renal Disorders

Lysosomal Storage Diseases With Predominantly Histiocytic Storage

Other Pregnancy-Associated Hematologic Disorders

Gelatinous Transformation and Other Bone Marrow Stromal Disorders

Crystals in Bone Marrow

Bone Abnormalities in Bone Marrow Specimens

Part IX: Myeloid Neoplasms

Overview and Classification of Myeloid Neoplasms

Protocol for the Examination of Specimens From Patients With Hematopoietic Neoplasms Involving Bone Marrow

Clinical Practice Guidelines for Initial Work-Up of Acute Leukemia

SECTION 1: MYELOPROLIFERATIVE NEOPLASMS

Overview of Myeloproliferative Neoplasms

Chronic Myelogenous Leukem