Part I THE MOLECULAR DESIGN OF LIFE 1. Biochemistry: An Evolving Science 2. Protein Composition and Structure 3. Exploring Proteins and Proteomes 4. DNA, RNA, and the Flow of Genetic Information 5. Exploring Genes and Genomes 6. Exploring Evolution and Bioinformatics 7. Hemoglobin: Portrait of a Protein in Action 8. Enzymes: Basic Concepts and Kinetics 9. Catalytic Strategies 10. Regulatory Strategies 11. Carbohydrates 12. Lipids and Cell Membranes 13. Membrane Channels and Pumps 14. Signal-Transduction Pathways

Part II TRANSDUCING AND STORING ENERGY 15. Metabolism: Basic Concepts and Design 16. Glycolysis and Gluconeogenesis 17. The Citric Acid Cycle 18. Oxidative Phosphorylation 19. The Light Reactions of Photosynthesis 20. The Calvin Cycle and the Pentose Phosphate Pathway 21. Glycogen Metabolism 22. Fatty Acid Metabolism 23. Protein Turnover and Amino Acid Catabolism

Part III SYNTHESIZING THE MOLECULES OF LIFE 24. The Biosynthesis of Amino Acids 25. Nucleotide Biosynthesis 26. The Biosynthesis of Membrane Lipids and Steroids 27. The Integration of Metabolism 28. DNA Replication, Repair, and Recombination 29. RNA Synthesis and Processing 30. Protein Synthesis 31. The Control of Gene Expression in Prokaryotes 32. The Control of Gene Expression in Eukaryotes

Part IV RESPONDING TO ENVIRONMENTAL CHANGES 33. Sensory Systems 34. The Immune System 35. Molecular Motors 36 Drug Development